We've been down this road a few times before. Any time Apple introduces a new OS, Line 6 monkey drivers don't work any more. If you're not getting any sound from your Mac, try this: go to System Preferences/ Sound and select your Mac's internal speakers. I bet you'll hear sound now when you play music on iTunes or YouTube.
Line 6 audio interfaces rely on drivers, and it usually takes a while to get updated ones, particularly if we're talking about a beta release. I have a backup interface that is simply plug and play. It works fine with Digital Performer 8 and 9.
If you have a bluetooth speaker, you can at least hear decent playback from your Mac, but if you have any kind of driver-dependent audio interface, you're in for a wait. Unless you re-install Yosemite.