HD500X - using either single coils or humbuckers, if i create a new patch and select any amp with no cabinet (this really accentuates the effect, but it's present with cab emulation) and strum the guitar at all loudly, very obvious and nasty digital clipping can be heard. The input pad helps a bit but does not get rid of it (and badly affects the tone).
Setting the second input to "VARIAX" instead of "GUITAR" or "SAME" goes a long way towards fixing it, but might cause other problems with dual amp (and obviously, dual instrument) setups. It still occurs at the very peak of my guitars' input levels, but is far less obtrusive.
This problem is completely absent with PRE-only amps, so it's obviously the power stage causing the problem.
I know line6 are aware of this – http://line6.com/supportarchivenew/thread/54572?tstart=0 – but the advice at the end of that thread said to start a new thread if the problem presents, and i haven't seen a really concise summary of the issue before.
I'm fully up to date w/ line6 monkey.