My HD500 causes the blue screen problem as well...and it's been going on now for about a year. I still don't have a fix and I've tried so many different possible fixes that I'm tired of trying. Despite that, I NEED to get the HD500 and my laptop to make up and be friends again. They worked together nicely for close to two years...but then came the BSOD crash! Days later it happened again...and then again but sooner. It kept getting more and more frequent until now I'd be lucky to get 5 minutes before a crash.
My workaround has been to replace the HD500 with an ancient Toneport UX-2, which runs beautifully with no crashes whatsoever. This proves that the problem lies with the HD500 itself or possibly some driver conflict. Everything is up to date, BTW. That was the first thing I checked.
I know this problem dates back to as far as 2014 and I have yet to see any posts by Line 6 folks that address this problem with HD500 AND HD500X crashing Windows 10. I and many others would be most appreciative if someone from Line 6 could shine some light on this very agonizing situation. I'm just about ready to list my HD500 on eBay or facebook or ??? I'd rather keep it, unless someone wants to trade me their HELIX...or even their HX Stomp. I'd take either one of those trades, once I made sure they didn't crash my computer.
Come on, Line 6, LOTS of folks are depending on YOU for help with this very old problem. That would go a long way toward giving extra credit to the Line 6 Support team...at a time when it seems that Line 6 Support could use some support. No offense intended...but this has gone on for much too long with no response [that I've seen] from Line 6.