Yes and Yes. I have been running Studio/Direct too. Thanks for the replies.
I also noticed the lack of volume control on the Spider. I keep the Master down on the Pod when I am not using the Spider and make sure to power down the Spider first before anything else when I am done playing.
I am running my Pod HD 500X left mono output into a Spider IV 75 watt, with the modeling disabled (Tuner button pressed while pressing the power button).
Studio/Direct, Combo Front, or Combo Power Amp?