Appreciate the response, I assumed it would be possible but didn't know if there were any shortcuts or recommendations from others doing something similar.
When selecting outputs in Mainstage (I assume it would be similar in Ableton) with the Helix selected as the main input/output interface I was given the options of Outputs 1/2, 3/4, 5/6, 7/8. So there seem to be at least four dedicated stereo output options on the Helix.
So, from what you're saying here, the Mainstage Outputs 1/2 are sent to the L/R XLR (assuming it might also be sent by default to the L/R 1/4") on the Helix?
What I now need to figure out is where the Mainstage Outputs 3/4 are routed by default (if they are at all), and if it would be possible to easily route Outputs 1/2 to the XLR and Outputs 3/4 to the 1/4".
This individual is doing something similar but he doesn't really explain how he has the outputs routed:
The main difference being that he is routing Mainstage as well as guitar and vocals through separate signal paths on the Helix, which I understand how to do. However, I am only using the Helix as an audio interface to get my guitar signal (straight out from USB 1/2) to Mainstage to control the Midi Guitar 2 plugin, there is going to be absolutely no guitar signal routed from the Helix. Again both the backing tracks and live sounds will be generated through Mainstage into two separate stereo outputs, that will then be routed through the Helix outs if possible.
EDIT:
So after going a little deeper into the manual, I came across a section I'd skipped over before, believing it only to be for reamping purposes:
Seems like it will be possible, but I'll need to route the two separate paths to USB 3/4 and 5/6 then create two signal paths in the Helix, one going to XLR and one going to 1/4". Am I overlooking something or could it be done another way?