I have the exact same issue with my Amplifi TT this morning.
Using USB on my Mac Mini and the Line6 updater, I have tried to re-apply the 2.50.2 firmware update and still didn't work.
I just downgraded back to the 2.10 firmware. At first looked like it was working, but when I took it over to my rig, did the same thing. Trying it again by holding [tone] and [tap] while powering on to force it to update mode...