I got mine to work!
I ended up installing the software onto my windows 10 PC. My problems were using the line 6 software on my MacBook.
I installed windows 10 onto my MacBook using bootcamp. Then I installed line 6 Pod HD500x drivers. Followed screen instructions, Then installed Monkey, followed screen instructions, then rebooted MacBook and HD500x. Once rebooted I opened Monkey, logged in and then went to license manager tab, logged into licenses manager, authorized my MacBook, then closed it out. Next, I installed Edit software, followed onscreen instructions but did not open edit program. I rebooted MacBook and HD500x, then opened Monkey, then opened edit software.
Now everything works! HOWEVER, when the Edit software is open I DO NOT touch knobs 1-4 on the HD500x, all my edits are done in software. Once edit software is closed it's ok to use knobs again. What I've noticed is that when you turn a knob while the edit software is open, the "sync" process is causing the communication USB errors. This is where Line 6 needs to work on a patch.
Hope this helps!