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Thank you all for the responses and advise. At this point, I will take the amp in to a Line 6 service center to get it diagnosed. Will provide an update once I get it fixed.

stevedenney, thank you so much for the reply! This is very helpful in my troubleshooting of the issue I'm experiencing. I have the FBV Express MkII foot-board that connects via ethernet cable to the Spider IV amp. As part of my troubleshooting, I disconnected the foot-board to see if the issue still persists and unfortunately, even with the foot-board removed I get the intermittent volume/sputtering problem. Here are all the things I've tried to fix the issue: - New instrument cable - Removed foot-board - Reset amp to factory defaults - Made sure firmware was up-to-date - Tried different guitars - Tried different patches and amp models - Tried different volume and gain levels - Ordered and installed a new Input PCB Assembly - Checked all circuit-board connections - Tried new power cable - Tried different power outlets None of the troubleshooting options above helped. Again, the issue I'm having is that after a few minutes of playing after turning on the amp, the sound cuts out and drops. If I play the guitar heavily, the sound sputters and is very distorted. Sometimes the sound will return to normal volume but then it will intermittently cut-out again. Also, when I plug headphones into the back of the amp, I still get the volume/sputtering problem. I'm wondering if this is a problem with one of the motherboards on the amp that might need to be replaced. Any other thoughts before I take it in to a Line 6 service center?

I'm having the exact same issue as the original post with my Spider IV 75 cutting out. Did this problem ever get resolved? If so, was was the fix?