Funny enough I’ve just experienced exactly the same thing. Feeding a signal direct to a set of powered monitors , audio was clean as a whistle, as soon as I run the audio from the PC through the UX2 the audio was distorting like some stage was being overdriven. Noticed the VU level on the UX2 was at the top of the scale, tried reducing the CPU’s main level output to 60% and fixed the distortion. Not the ideal solution as it has resulted in lifting the noise floor….similar solution to Timura above …love to know if anybody has discovered a better solution.