I am wondering about this as well.
The user manual had no information at all.
As far as I am aware they cannot receive MIDI feedback from the DAW although from what i have read line 6 could fix this relatively easily with an update however it seems like people have been waiting for this update for years and nothing has happened.
I think you would be able to use a tuner in MIDI mode provided that you didn't change the midi the function via the control feature. In saying this i don't think you can use it as a midi control button and a tuner.
Hope this helps.
If anyone else has information that would be greatly appreciated.