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rzumwalt's post in Treble booster and Helix rack was marked as the answer
I have used one in the fx loop. I wasn't specifically aimingĀ for a Brian May tone, but it has pretty much the same effect on the modeled amp in helix as you would expect it to have on a physical amp. More overdrive, volume, and highs, depending on the amp model it's going into and the amp settings, of course.