Im Having the same issue. not an IT guy by any means but I know my was around win 10. I wiped my whole pc clean, reinstalled old drivers and new...... same problem.
Mine is actually " L6PODHD5SE64.sys " If you anyone figures it out please share. I like the line 6 editor on pc. thats the only reason I need it connected. I play Rocksmith and wanted to change to my own tones in It, but I might just run the PC and line 6 sepparatley into a small mixer instead