I was having this very same problem today. I finally took the USB connection off of one port and put it into a different slot. I don't remember but it was either moving it from a 30 USB to a 2.0 or vice versa. Windows would see the device as would the Line 6 Pod Farm but no input or output to it. There were also long delays anytime you tried to access the properties and what not. Re-installing the drivers didn't help. I don't know if the USB version is the issue or it just needed to be enumerated on another port. Works great now.