My experience: my helix froze today for the first time since the 2.12 update earlier this week. The freeze was upon startup, but I was at a gig and nothing else was connected, no USB/computer connection. The Helix finally booted successfully after the third attempt. Also FWIW the patch I was using was freshly created after the update, and the update was done per all of the instructions including the global reset.
I have been so blown away with this awesome unit and it's the first modeling rig I've had that truly replaced a large analog pedalboard, but I have to admit I am a little concerned now. Hopefully there's something Line6 can find and address quickly.