I have the same problem. Spider V Remote version 2.00 worked fine on my older Windows 10 machine. I got a new PC and the Remote program would attempt to start for a couple of seconds and then terminate.
I worked with Line 6 support for quite a while on this problem. They seemed to focus on Microsoft dot-Net Framework versions. Had me try installing/uninstalling various versions. In the end, nothing worked. The Line 6 guy apologized and said they had no solution at this time. (This was a couple of months ago)
Thankfully, Remote version 1.03 works fine. Seems like the only solution is to uninstall version 2.00 and download/install version 1.03.
