Hi, elvissideburns84.
I'm currently using that setup: POD HD500x+Fender Blues Jr. It sounds awesome with a few teaks on the amp:
(You will have to experiment, but take this as a base)
Volume at 5-7, Middle 9-12, trebble 6, bass 4, no reverb, master at taste ( I use it at 2-3 for small gigs). Set up the volume of the pod below the 50% and you will be fine. Please, please, please turn the global eq off in your pod unit.
It is probably too late for the answer, but, I hope it becomes useful for other people searching for this information.