Here is a starting template that will allow you to switch between two amps and assign a different powercab speaker model to each one.
When you first call up the patch it will send a program change to Powercab Program 1-Vintage and then change the speaker to a Jarvis. Footswitch 7 (Fender-Vox) switches between a US Deluxe Vib w/ Jarvis and an Essex A15 w/ Essex.
Of course, you are free to change the amps with the Helix editor and change the speaker models in the Helix command center.
NOTE: To be able to change programs via MIDI (to the Powercab, for example) by using an Instant Command in Helix, you must turn OFF the MIDI PC Send under Global Settings > MIDI/Tempo.
Amp_PC toggle.hlx