Dave Hart,
Jeeeesus christ man - the MicroSD card was it!! I'm running an HP Spectre x360 laptop, didn't have the Drive 0 problem or any other mentioned here or anywhere, just bought Native and couldn't load it - would crash Ableton and Reaper wouldn't recognize - and through the troubleshooting process I realized I couldn't open HX Edit anymore either.... removed the damn SD card, everything worked. MAN!! So much uninstalling, reinstalling, time wasted. Thank you!