Hi everyone I like all the inputs on this topic, I currently am running my Pod HD 400 into my Amplify 150 via 1/4 with the amp setting on the amplify set to no amp, using the pod as the amp and all effects and so far have been happy with the sound I am getting. I recently have run a split into 2 amps from the pods L and R outputs using the amplify 150 and a Tube amp set clean and both amps balanced in volume, then using the pod as the main volume, setting each bank on the pod to taste, anyway I"m having fun with the amplify and the pod.I am going to try the aux of the amplify to see what the sound difference is.Will post later if I can.