Just curious etregoning87, did you follow through and buy the M-Audio cable? If so, did it resolve your connection issue? I'm having the same issue getting my POD 2.0 to connect to my MacBook Air (OSX 10.12 Sierra). When I try to update the Firmware, I get the following dialog box from Line 6 Monkey v1.75:
(Code 8000900C) MIDI device timed out waiting for response. Make sure the cables are still connected and try again.
Before I send back my cheap cable and try out the M-Audio at 2x the cost, was hoping to hear if you're now up and running. Thanks.