I'm having a similar problem with my UX1. Stopped working entirely after the W10 upgrade. No input or output; it's recognized as an audio device, but setting it as 'default' doesn't actually change the audio output â€” it still pumps through my main speakers as though I hadn't changed anything. Changing the sample rate just resulted in super-slow video playback and screeching audio.
My support ticket was submitted on 7/31, almost two weeks ago. It was last updated on the 3rd, almost a week and a half ago when the respondent from support literally asked me to repeat nearly everything I'd written in the original ticket. I love the OS and all my other apps work just fine. I'm shopping around now for an alternative, so hopefully Line 6 gets their butts in gear.