talonmm's post in Hide the physical amps characteristics when using Helix? was marked as the answer
Ok, you asked for it....
I don't know anyone else that runs a rig quite like mine but it works.
I have two helix units, one for gigs and one stays home.
on the home front I use two marshall stacks, one for left side, one for right. - I do not play loudly, but the two stacks on opposite sides of the room fill the room nicely with rich sound.
I buy the very cheap, used solid state marshall heads and try to amplify the sound to drive the cabinets without any added overdrive.
the system sounds awesome - and I use the helix for the cleanest cleans to the 5150 amp heads - all the sound charasterics are derived from the helix not the marshall.
I have had quite a few guitarists over and they all rave about the sound
no reason a helix can not be set up this way and work fine with some tweaking
and I do not use effects loops, i go directly from helix to the guitar inputs on the two heads using 1/4" cables