Just to add to this post I'm getting no joy with Line 6 Monkey and Windows 10.
Just hangs for a while on start finally opens but does not connect to my Pod HD500, JTV59 or Guitar port.
Says it can't connect to the server but I am able to log in.... Have reinstalled monkey and drivers but still no luck as yet.
Read a few posts about changing sound card parameters but all have been to no avail.
This is just for everybody's info really, as I agree we will have to wait it out for a Line 6 update.