I am having the same problem. When i try opened up 'My Devices' under 'Computer' the device is shows up with an exclamation mark next to it telling me that i have to update the driver. Problem is, the line six software isn't detecting the device at all. Likewise, i keep getting the same dialog about 'connecting using MIDI' even though no such outputs or inputs exist.
It's frustrating to not even be able to get off the ground with a fresh software install.
Feedback would be appreciated.