I just set up a preset to use with my acoustic guitars and a vocal mic. Got the Vintage Pre on both and Tube Comp on the vocals with a plate reverb. Separate verb on the guitar, Dimension and Delay. Sounds great through the head phones and I'll be running through QSC K-12s on the road. The K-12s have 2 channels of inputs each so I could theoretically run three mics if I had to and not break out my mixer. But I play solo a lot, so the mic input on my HD500 saves me time and work... no mixer.