The solution I found is for Mac, the OS I still use is El Capitan installing Reason 6.5, also tried it in Mavericks.
1) Go to applications and in the reason folder to the reason app icon, right click on it and press show package contents.
2) Go into the folder “Contents” and then “Resources” and then into the folder “Installation”.
3) inside that folder you will find a package named “Line 6 TWXT Framework”
run the package and restart the computer. Now reason should be able to load.
If that doesn’t work you might need to run the “Authorizer.pkg”
”CmDriver.pkg”
and ”CmKext.pkg” inside “Resources” too.
Hope it helps someone, but try it at your own risk.