I have had my Helix tor over a week. I have used it with my 50th anniversary strat plugged into a Mesa MK VI combo with 2 cables . One from the guitar 1/4inch out to the Helix guitar in. 2 guitar out on the Helix to the effects return loop on Mesa. . There is a learning curve really only because the choices are endless.Phone support was quick friendly. very helpful and unrushed. Product sounds and tweakability unmatched in my 40 years of professional performing,recording and song writing. Build is tank ;like Thanks Line6 and Yamaha! Note I was not paid or rewarded for this short opinion.I don't work for Yamaha Line 6 or any music gear manufacture wholesaler or retailer . I just like the product ! a lot.