SOLUTION: For anyone else facing this same problem, I had never had the issue until I upgraded my computer and my interface. I wound up with the dreaded USB cable noise after the upgrade. Luckily, I had a EBTech Hum eliminator floating around, and I'm happy to report that 100% eliminated the noise. So, if you're getting the USB cable noise, this will solve your problem. https://www.amazon.com/EBTECH-HE-2-Ebtech-Hum-Eliminator/dp/B0002E4YH4 I'm using the 1/4" outs, so this model worked for me. There are other models that support XLR.