I tried to install WorkbenchHD on two systems running El Crapitan today. One - my laptop worked fine, the other (on my iMac) loaded, but wouldn't "find" the guitar via USB. I did both from the monkey (as the downloadable version posted at Line6 support does not seem compatible with the new OS). I have come to expect this sort of hit and miss program operation from Apple nowadays with there last two operating systems. As my laptop has very little on it other than Apple programs, and my iMac has plenty of other non-Apple programs, I am suspecting a conflict from an outside vendor program and I am trying to figure out what processes might be blocking the USB connection recognition. I will repost if I figure it out.