I'm one-week in to exploration of a similar idea:
I have a large pedalboard (32" x 16") utilizing a Mobius, Timeline, Eventide Space, Empress Tremolo2, and Pigtronix Infinity Looper.
The whole thing is controlled by a RJM PBC (similar to your ES-8).
I also have analog drives, boost, compressor, etc. in the PBC loops.
So far, I can say the HX absolutely covers what the five "big box" pedals were doing (plus more).
I'm using one of the HX audio loops for my analog drive pedals (which can be positioned anywhere in the signal chain on a per preset basis).
I have the compressor before the HX input.
The second audio loop is dedicated for amps with effects loops (or perfect for auditioning the latest pedal du jour).
With the drive loop "on," I manually turn on and off the pedals I need - so no more complex presets but honestly I am always adjusting drive and boost pedals on the fly anyways.
I have to say, so far I'm really happy with the results (and my new pedalboard which is half the size!).