This is my setup. I have a Helix into 2 Spider V 120's I just set this up like this. I am currently using it without any amps, effects, cabs, etc setup on a patch using the normal input on the Spider V so I don't have to hit the tap buttons every time i play to bypass the preamp.
I haven't tuned everything and made patches yet I just built this to replace my old setup of a pod pro hdx, spider v, 2x12 cab, triaxis, ada mp2, peavey classic 60 60 and a lexicon mx400.
Wanted to make it less complicated and save some money, bought the Helix, rack case, foot controller, expression pedal for $1400 then I bought a Spider V with FBV, transmitter for $100 off offer up. Already had the other Spider V for $200 off guitar center used. For my whole setup there I am in for about $1850.
Let me know what you think?