IMO playing the Helix through a good *full range* powered speaker sounds pretty darn real, once you’ve tamed the high frequencies. I have an excellent tube amp, a couple of adequate tube amps, and have owned many more excellent tube amps in the past, but am very happy to gig the Helix when I want or need to travel light.
To get over option paralysis, just choose a single Helix amp you kinda like and stick with dialling that in (just pretend it is 'your amp' rather than one among many): taking top end off cabs/IRs is my usual first step, then tweaking master, sag & bias settings to dial in whatever 'tube' feel I'm looking for.
If you want to use your 1x12, get a cheap class D amplifier and turn off your Helix speaker IR/cab sim. The Harley Benton GPA-100 recommended above is absolutely fine. Even a cheap Chinese amp board in a spare box paired with a old laptop power supply would be enough to test the idea out, though you'd probably need to ground it to prevent hums and buzzes.