I'm getting awesome results using this chain:
strat with humbucker set to bridge (use a heavy pick picking close to the bridge saddle - original recording was a '59 les paul)
obsidian 7000 fuzz (original recording was a Gibson Maestro fuzz-tone)
US Double Nrm amp (original recording was a fender dual showman)
Bitcrusher (just a little gain 13.5, mix 29%)
eq low and high cut (low cut off, high cut 6.3kHz - this keeps the highs from being to harsh)
'63 spring
transistor tape delay
eq with mid gain boosted
volume patch (52%)
you can stick a hard gate after the bitcrusher if you want
I created a second snapshot with the fuzz off for the verse