I had the same problem, Win10 crash when I connect or use the HD500X driver. I followed your suggestion and completely unistall McAfee anti-virus, the problem was solved and now its working great both on 2.0 and 3.0 usb ports. Thanks tRuE_pLaya!
I posted a proposal for including an option for panning the looper in the next pod hd500x firmware update. You can vote for it here: https://line6.ideascale.com/a/dtd/Pod-hd500x-looper-panning-option-firmware-update/973156-23508?submitted=1 The more votes it gets the more chances they implement it. Thanks!