The cheaper USB A to B type cables give off a nice bit of high frequency noise, I've had that issue with Katana Head in the past and now with HX Effects,
most cheap USB cables will do the same thing, it's worth finding a quality well shielded A to B type USB cable with a 'Ferrite Bead' in line to help eliminate that component at least,
I notice a little more noise floor in the send/return but can't be sure if that cable upgrade will help, I just change settings then disconnect.
Something like this will be a lot better than the standard issue Boss or Line6 USB in high frequency noise at least;
https://www.amazon.com/Tripp-Lite-Hi-Speed-Ferrite-U023-003/dp/B008VOPCGY
