Rather than start a new thread, I will echo the noise comments.
Not all patches have the problem, so I think that rules out cable/grounding issues.
I started with a guitar cable to my Atomic CLR. A TRS was much more quiet, is that what I should use?
It's not patch gain levels, because I get it on WhoWatt at low gain.
I don't want to resort to a gate, I'm not a djenter.
I'll try all the effects one by one