Absolutely! You can absolutely combine the Line 6 Helix with other guitar plugins like Neural DSP's. You can use the Helix's effects blocks, such as fuzz and delays, alongside the Neural DSP plugin within your digital audio workstation (DAW). To get started, simply connect your guitar to your audio interface (Focusrite 8i6) and route the signal through both the Helix and the Neural DSP plugin within your DAW's signal chain.