I have always bypassed the amp modeling and relied on whatever head I was using for my gain, so the AMP modeling when bypassed allows you to use the Line 6 Compressor, and if you set the Threshold at 0, you can crank the gain on it to give you a cleaner volume boost. I had done that before, and I had two channels set up, one for rhythm and one for lead, but it never worked until I ran it through the effects loop. Once I did that, the Comp started working a little too well, I had to turn it down, and the Amp Bypass Channel Volume is more noticeable as well. So, basically, once I ran it through the effects loop on my head it started working