Yes it's very familiar for me, and this is NOT the USB Drop-out. This is a bug from microsoft. The problem exist since win 7 and happen with wide range of audio-USB hardware and computer. To be sure, next time the sound stops, just try to play/record something with an ASIO software. If it works, it will confirm the microsfoft bug. I know few solution/workaround :
Use a PCi/USB card : I didn't test (i use a laptop), seems to solve problems but produce sometimes other issue :-s . It's seems also solve some "crack and pops" issue.
Use ASIO mode only - It work but it's (very) restrictive :
In the windows mixer, disable the POD X3 for playing and recording. You will be unable to use the pod X3 in DirectX mode (for example, you will be unable to use audacity)
When you want to record something, just use an ASIO sofware (reaper, cubase, ableton live ...)
When you want to jam with youtube, guitar Pro, winamp ... just branch the phone output of you computer in the CD/mp3 input of the pod.