Ends up the headphones were the culprit. Bose headphones must have been reproducing only L or R signal in both ears, not sure. Anyway, sorry Line 6… you guys have and continue to amaze me with your quality products, from my very first "kidney bean" POD, to the X3 Live and now my HD 500x. Truly professional simulations, I'm so fond of running through a FRFR system that I can't imagine going back to tube amps. Thanks!