I don't think you will be able to control the Spider, but you can use the Spider in power amp only mode. It's been a while since I had the Spider, but I remember that you can switch the amp into power amp only mode by holding down the Tap button when you switch it on (maybe someone can correct me here if this isn't the right button). In this mode you can get the Pod to power amp directly by plugging into the normal input jack on the Spider, so your pods sound will not be affected by any of the Spiders sounds (the Spiders modelling and effects are all disabled). Be careful though because all of the amps controls will be disabled too, including the master volume. Make sure you set your Pod's master volume to a low level before you switch it on otherwise it will be very loud! The amp will be at 100% volume all the time in this mode. I used this setup for a while and it worked well. Also, because the amp is at full volume it is best to switch the Pod on first, the the amp second and reverse this when switching off. This is the way I would use any power amp with the Pod anyway to avoid any speaker pop when switching the Pod on.