For quite a while now, I've been using the A30 Fawn (Nrm) with the Hiway cab and SM57 on-axis mic ALOT, with mid-focus EQ (hi-pass 15%, lo-pass 80%, wide Q of 5-25%). I was using the default cab (silver bell I think?), which sounded okay.
But once I switched to the Hiway + '57, the amp suddenly came to life. There was that restored chime and sparkle that was lacking before. The highs needed to be tamed, along with the bass, which can be easily done with the amp tonestack plus mid-focus EQ. At the amp, bass and presence is 0-15%, with cut around 80%, treble around 65%. Also boosted the "thump" DEP to compensate for the bottom end. Drive and "master" DEP around 40-80%, adjust to taste.
With my H-H guitar, it works so well that I use it almost exclusively now, replacing my old favorites, including the Black Panel Pete, which I felt sounds better with single coils. It takes the Screamer (TS) and Classic Dist (Rat) really well. It's also versatile. After rolling off the tone knob a little, it sounds great for ambient stuff with a delay and the Particle Verb.
At church, with a few variations, it covers almost everything I need. There's the excellent Soldano Crunch for heavier stuff, and a few amp-less synth and ambient patches, but that's it. I'm not sure if it'll work with your guitars, but no harm trying. Just don't be turned off by the initially sharp treble, it's easy to get rid of that.
I guess the lesson here is to experiment with different amp-cab-mic combinations, and don't be too quick to judge a particular combination before trying some pre/post EQ. Quite often, the default cabs/mics may not be the best choice. So please share your recent Pod discoveries!