I use the HX Stomp primarily for practice through a guitar amp, but would like sometimes to take it straight into my iMac's USB without having to fire up the amp (among other things). My iMac goes out digitally to a DAC (a DAC without an ADC isn't seen by the computer, btw, so can't be configured in Audio MIDI Setup -- but there's no need to do that anyway), then to my studio monitors (Dynaudio BM6As), not computer speakers.
It's a lot more work to patch the HX Stomp's analog outputs into the system than it would be to just go in USB and set the computer's input to the device, leaving the computer's output on Digital Output. It requires me to connect two cables to the Stomp's analog outs, set them to line level, route the signal into another interface, etc. I like the HX Stomp for a convenient single source for guitar effects, but it would have been even better if it were plug-n-play with the computer. That said, it's not so much the fact that it can't be done but rather that the user manual is unclear about it.