I have replicated my far too large pedal board within the Helix, using my DT25 head and cab with the 4 cable method. Honestly it took about 20 minutes to do, so simple.
I brought my Hovercraft Falcon 50 head home to make sure what I had replicated carried over to that head. I was amazed at how clearer my effects sounded and the overall presence of my amp was brighter.
At rehearsal last night I was able to open it up out of my 6x12 cab, my band mate's heads snapped back at how clear and present it was. We are a loud band that plays in C Standard, so I was weary that the lower register would be muddy. In reality, I think the patch cables in my pedal board (even though I have an ES-8 looper) were sucking tone.
I have a bit of tweaking to do with the reverbs, they seem to kill the bottom end a bit too much and some general levels, but overall I am glad I made the switch and look forward to less problematic gigs.