I've been told that some amps' channel switching "do not play well" with MFX like my Helix LT. I have a Peavey Classic 30 that I could not get the channel to change when I was using my GSP1101 amp channel switcher output, nor when I tried while using my new Helix LT. I searched on all the forums and subreddits and only found lots of others with the same problem with their particular amp (looked like it was mostly Peaveys). So I went to the manufacturers... Line 6 support and Peavey support both had no clue how to make it work and could only tell me "it should work!" So I did a bunch of testing on my own and found the problem seemed to be a potential difference between the Helix & and amp that was incompatible.
And I developed a circuit that has a relay to isolate the two but still enable the amp channel (and reverb) switch. The video is a test of the first build of the circuit connected between the Helix EXT AMP and the Peavey remote jack, both reverb and channel 2 are activated by Instant Commands set for either tip, ring, or both. The pic below is the in-work box to house the circuit that will go on my pedalboard next to the Helix.
When I find time, I'll post the circuit schematic somewhere for others to use.