I can't work with USB 3.0 and Pod HD500x. Sometimes it works for a few days, but suddenly the system crashed several times. From one moment to the next I get a second latency on every action, even starting the sequencer. When I'm lucky I get it to save the projekt before it crashes. And then it crashes several times, with blue screen talking bout podhd driver problems. No way to risk it in a live setup... I use asio4all now and connect my Asus Audio out to the aux input minijack of my hd500x, what was not my intention, of cause. Now I must search for an alternative. Or a better line6 driver.