I opted for the M5 first in the signal chain with expression pedal, into Boss Super Overdrive into HD147. I love the M5 to be able to add U-Vibe, Wah, Compression, and Harmony effects in conjuction to the onboard effects and volume controlled with FBV. With the bonus of having extra delay, chorus, script phase, and OD without taking up floor board real estate and doing river dance for patch changes while keeping input signal maximized. Also works great with my Ampeg BA500 2x10 combo although am thinking about getting an M9 just for bass duties