I thought of running Podfarm not in DAW, connecting guitar to Focusrite's instrument input 1, sending signal from that input to DAW and sending the same signal on one of outs. Connect that out with gx input and gx output sending on input 2 of Focusrite. In virtual mixer would be able to route signal from my DAW and from input 2 to speakers. I think it would do the trick, but I'm not sure if it's really possible to lower the latency so that it will be possible to play or will windows handle 2 cards simultaneously.
What I want to get is clean signal on guitar track so that I will be able to run podfarm as plugin and have everything under control. Additionally I'd like to hear guitar with effects on it.