After checking if everything works properly as it was suggested above, it seems to me that it is more a matter to find the best cab/mic sim (for you).
The Helix offers many (good) stock cabs, but trying them can be frustrating because there are many options, and what's more the editing is not arranged well (for example every time you change the speaker, all the other parameters change into the default values!).
In my case, I prefer to try some IR files because at the end it is easy and quick. I add some hi-cut and lo-cut, and in the Helix often even some extreme values are good (for example something like 110Hz low cut, and 4.5kHz high cut aren't that weird with Helix!).
Without trying thousand IRs, you could start with these very good FREE impulses from some commercial sites, such as:
http://valhallir.at/en/shop/valhallir-at-teaserbox/
and
https://www.ownhammer.com/store/index.php?main_page=product_info&cPath=181&products_id=411
(just use the "quick start" folder)
You'll have about 50 impulses that are a good starting point imho.
I'd add that it is even easier to find a good IR, and then later to try to get close to it using as alternative the stock cabs and mics of Helix, because at least you have a reference tone.
By the way, did you try my own IR that I linked in a message above?
If using Impulse Responses isn't your target, try to focus on just few single stock cabs and mics in the Helix, so that you have a smaller choice that often gives a good result, such as for example:
MICS: 4038 or 121 (ribbon mics)
CABS: 2x12 Blue Bell, 2x12 Silver Bell, 4x12 Greenback20, 2x12 Match H30, 2x12 Match G25
EARLY REFLECTIONS: zero
Lo-Cut: around 100-130 Hz
Hi-Cut: between 4kHz and 6kHz
Distance: generally I prefer close to the grille (1" or 1.5")
As to the hi/lo-cuts, you could place an additional fx block after the cab/mic sim, using an eq block with the low cut and high cut. This way it will be fixed, while you test the other combinations of speakers and mics, and what's more the cuts in the separate eq blocks are steeper (and may be more pleasant) than the ones you get in the cab block.