Hi there.
Re: Floor Pod Plus.
I have found out, time and time again, with several different amps (Marshall, Mesa, Laney, Crate and a few others) that, to get the best tone possible, you need to do the following:
1.) Connect your guitar to the input of the POD
2.) Connect the Left or Right output of the POD, directly to the input of your amp.
3.) For new Guitarists who aren't familiar with how to accomplish killer tone, the trick here is, to use ONLY the clean channel your amp. This is almost always going to be the case with any preamp such as the Floor Pod Plus. The reason is, if you use distortion from the POD through the dirty channel on the amp, it's going to sound absolutely terrible! Trust me on this. Yes, the POD is an effects processor as well but trust me, you do NOT want to run this unit through an effects loop on an amp.
4.) If you're going to use stompboxes, make sure you DO run those through your effects loop on your amp BUT ONLY if they are delay units or modulation units such as Chorus, Flanger, Phaser and the like. If you don't like the compressor or the distortion on the pod, make sure you're putting these in front of the POD, NOT after it. Noise suppressors, Gates, Distortion, Wah's and the like, need to be put before the POD, then to the input of your amp. For example:
Start with Guitar -> Noise Gate/Suppressor -> Compressor -> Wah -> Distortion pedal - > POD -> AMP input.
For modulation effects as described above, run these throught the effects loop (if you have one on your amp) as follows: Chorus -> Flanger -> Harmonizer -> Phaser -> Tremolo -> Delay
I can tell you from years of experience and with some of the most expensive gear that pro's use, connecting these things in the manner above, has brought out some of the best tone a Guitarist could imagine! However, remember that, not all amps respond the same way so, you may have to experiment a tiny bit here, with the above configuration. And as always, tone is subjective so, you may find yourself tweaking your POD and/or pedals.
Enjoy!